A robust and powerful two-step testing procedure for local ancestry adjusted allelic association analysis in admixed populations
نویسندگان
چکیده
منابع مشابه
Estimating local ancestry in admixed populations.
Large-scale genotyping of SNPs has shown a great promise in identifying markers that could be linked to diseases. One of the major obstacles involved in performing these studies is that the underlying population substructure could produce spurious associations. Population substructure can be caused by the presence of two distinct subpopulations or a single pool of admixed individuals. In this w...
متن کاملLocal Ancestry Inference in Admixed Populations
Contemporary human sub-populations exhibit great differences in the frequency of various alleles, or the set of variations of a particular gene. Advances in genome sequencing have rapidly improved speed, cost, and accuracy, allowing unprecedented opportunity to map the functionality and location of such genetic variation. Of particular interest is the mapping of disease associated loci in the g...
متن کاملAncestry specific association mapping in admixed populations
Genetic association studies have during the last decade proven to be a powerful approach to identifying disease-causing variants. However, many populations, like the Greenlandic Inuit population, have recently experienced substantial admixture with other populations, which can complicate association studies. One important complication is that most current methods for performing association test...
متن کاملAdjustment for local ancestry in genetic association analysis of admixed populations
MOTIVATION Admixed populations offer a unique opportunity for mapping diseases that have large disease allele frequency differences between ancestral populations. However, association analysis in such populations is challenging because population stratification may lead to association with loci unlinked to the disease locus. METHODS AND RESULTS We show that local ancestry at a test single nuc...
متن کاملRobust estimation of local genetic ancestry in admixed populations using a nonparametric Bayesian approach.
We present a new haplotype-based approach for inferring local genetic ancestry of individuals in an admixed population. Most existing approaches for local ancestry estimation ignore the latent genetic relatedness between ancestral populations and treat them as independent. In this article, we exploit such information by building an inheritance model that describes both the ancestral populations...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2017
ISSN: 0741-0395
DOI: 10.1002/gepi.22104